CBD: what are the effects?

CBD info

CBD, also called Canabidiol, is conferred many virtues.
Unlike its cousin THC, CBD does not cause any psychotropic effects (see article “CBD and THC: 2 cousin but different molecules”).

Based on research to date (i.e. CBD and its effects are still being researched), CBD is said to have effects:

Anxiolytics, antidepressant and anti-stress:
It is possible that CBD can have effects on our mood! Although the therapeutic properties of this molecule have been little studied to date, it seems that CBD reduces anxiety, depression and stress.

  • CBD and anxiety :
    whether anxiety is traumatic or whether it originates from genetic or environmental factors, it is nonetheless an illness that affects, to varying degrees, daily life. Although very often requiring deep psychological work, anxiety can also be relieved with substances with anxiolytic effects. This is the case with CBD. A 2011 Brazilian study (the preliminary report of which you will find at this link: https://pubmed.ncbi.nlm.nih.gov/20829306/ ) demonstrated that CBD had beneficial properties in terms of reducing anxiety . Indeed, its action on the limbic and paralimbic areas of the cerebral cortex would reduce anxiety and particularly social anxiety (speaking in public, socializing, approaching strangers, etc.)
    Another study, Spanish this time (the report of which you will find on this link: https://pubmed.ncbi.nlm.nih.gov/26711860/), provides new information on the anxiolytic properties of CBD. She also concludes that CBD offers rapid and long-lasting antidepressant effects.
  • CBD and depression:
    The competent authorities do not yet recognize CBD as a therapeutic agent in the treatment of depression. However, it has been demonstrated by clinical studies that CBD resulted in an inhibition of the recovery of serotonin (sought process identical to that of antidepressants).
    It appears that CBD acts very favorably on serotonin (happiness hormone) and thus plays a major role in mood and stress management.
  • CBD and stress:
    Stress is a daily ailment for many people. Our society and our lifestyles are causing stress in more and more people.
    The consumption of CBD would generate a more or less significant feeling of relaxation depending on the dosages chosen and the individuals.
    Vanderbilt University in the United States conducted a study which demonstrated that brain cells create their own endocannabinoids whose mission is to reduce the feeling of stress. CBD, by binding to our endocannabinoid receptors, would greatly help to eliminate negative behaviors and at the same time act on cell longevity.

A London study suggests that CBD would help regulate abnormal brain activity in regions involved in psychosis (striatum, medial temporal cortex and midbrain). This could pave the way for a new class of side-effect-free antipsychotics.
A Californian study is more particularly interested in the effects of CBD on schizophrenia. This study could also lead to a new alternative to traditional treatments.

Some medications aimed at reducing epileptic seizures and their intensity use CBD. This is the case, for example, of Epidiolex ©.
Various studies have shown that CBD has comparable efficacy to other known antiepileptic treatments. However, it could prove interesting for certain rare forms of epilepsy that are refractory to drug treatment.
Concerning other forms of epilepsy such as focal epilepsy of structural origin (following a brain lesion) or idiopathic generalized epilepsy have not yet been the subject of targeted and exhaustive studies and the effects of CBD remain to be proven.

CBD appears to reduce inflammation and is found to have powerful properties that relieve inflammatory conditions. Promising results have been observed regarding the mediation of immune responses associated with various diseases such as depression, hypertension, or even Alzheimer’s disease. CBD could help fight oxidative stress, the latter has shown immunosuppressive effects on microglial cells and macrophages (cells essential in immunity and inflammation). It has also shown convincing results regarding the reduction of chronic inflammatory pain and intestinal inflammation thanks to the activation of glycerin receptors.

The consumption of CBD has an effect on the CB1 and CB2 receptors (see article “Understanding the receptors and the endocannabinoid system”) linked to the feeling of pain for certain pathologies, in particular chronic inflammatory pathologies. The analgesic property of CBD is associated with an anti-inflammatory property through an effect on adenosine receptors. CBD would thus prove to be particularly effective in relieving patients suffering from chronic pain in conditions such as rheumatoid osteoarthritis and fibromyalgia. In adjunctive treatment to treat neuropathic pain and muscle pain, cannabidiol tends to become more democratic.
CBD also proves to relieve some patients undergoing chemotherapy by helping them to fight against its side effects (pain and nausea).

On falling asleep and drowsiness:
CBD would have a strong potential to regulate the sleep/wake cycle. Various studies have highlighted the fact that CBD would improve sleep and thus make it deeper and more relaxing.
Sleep aids, for the most part, are direct sedatives. This is not the case with CBD, which on the contrary can promote awakening during the day. This would be due to the interactions of CBD on the endogenous cannabinoid system. Research indicates that CBD has a beneficial effect on drowsiness, a disorder that results from daytime exhaustion caused by poor sleep at night. CBD therefore promotes a better overall sleep cycle, but in no case will this molecule put you to sleep immediately like sleeping pills.

On addiction:
While CBD is well known in the treatment of addictions such as alcohol and nicotine, it is also becoming the subject of study to manage other addictions such as cocaine, heroin, etc. Useful in addition to the treatment of certain addictions, CBD is in no way a substitute for a strong addiction, and consulting a doctor or an addictologist remains essential in all cases of addiction.

The above list of effects is not exhaustive and much research is still being done.
The progress of research and studies does not allow to date to substitute a medical treatment with CBD. However, CBD can be taken as a supplement with the advice of a doctor. The latter will tell you in which form(s) to take this molecule, and will tell you a dosage to respect.

The use and consumption of CBD-based products still requires some precautions. (see article “CBD: precautions, interactions and side effects”).

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